Search results for " gamma-Chain T-Cell Antigen Receptor"

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Characterization of lung γδ T cells following intranasal infection with Mycobacterium bovis bacillus Calmette-Guérin

2002

The lungs are considered to have an impaired capacity to contain infection by pathogenic mycobacteria, even in the presence of effective systemic immunity. In an attempt to understand the underlying cellular mechanisms, we characterized the gammadelta T cell population following intranasal infection with Mycobacterium bovis bacillus Calmette-Guerin (BCG). The peak of gammadelta T cell expansion at 7 days postinfection preceded the 30 day peak of alphabeta T cell expansion and bacterial count. The expanded population of gammadelta T cells in the lungs of BCG-infected mice represents an expansion of the resident Vgamma2 T cell subset as well as an influx of Vgamma1 and of four different Vdelt…

CD4-Positive T-LymphocytesCytotoxicity ImmunologicT cellImmunologyGene Rearrangement delta-Chain T-Cell Antigen ReceptorEpitopes T-Lymphocytechemical and pharmacologic phenomenaBiologyCD8-Positive T-LymphocytesLymphocyte ActivationLymphocyte DepletionInterleukin 21MiceAntigenT-Lymphocyte SubsetsmedicineImmunology and AllergyCytotoxic T cellAnimalsTuberculosisIL-2 receptorAntigen-presenting cellLungAdministration IntranasalCells CulturedGene Rearrangement gamma-Chain T-Cell Antigen ReceptorT-cell receptorhemic and immune systemsReceptors Antigen T-Cell gamma-deltaAcquired immune systemFlow CytometryMycobacterium bovisMice Inbred C57BLstomatognathic diseasesmedicine.anatomical_structureImmunologyCytokinesCell DivisionT-Lymphocytes Cytotoxic
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Gamma-delta T-cell lymphomas.

2009

Peripheral T-cell lymphomas (TCLs) are uncommon neoplasms, accounting for about 12% of all lymphoid tumors worldwide. TCLs in which gammadelta T-cell receptors are expressed (gammadelta TCLs) are extremely aggressive and rare (<1% of lymphoid neoplasms). gammadelta TCLs originate from gammadelta T cells, a small subset of peripheral T cells with direct antigen recognition capability acting at the interface between innate and adaptive immunity. Two distinct gammadelta TCL entities are recognized: hepatosplenic T-cell lymphoma (HSTL) and primary cutaneous gammadelta T-cell lymphoma (PCGD-TCL). HSTL is a well-characterized extranodal lymphoma that has a disguised onset, secondary to intrasinus…

Hepatosplenic T-cell lymphomaT cellGene Rearrangement delta-Chain T-Cell Antigen Receptorchemical and pharmacologic phenomenaprimary cutaneous gamma delta T-cell lymphomaImmune systemmedicineHumansGamma delta T cellLymphoma T-Cell CutaneouClinical Trials as Topicbusiness.industryGene Rearrangement gamma-Chain T-Cell Antigen Receptorgamma delta T-cell receptorMedicine (all)Peripheral T-cell lymphomaLymphoma T-Cell PeripheralReceptors Antigen T-Cell gamma-deltaGene rearrangementmedicine.diseaseAcquired immune systemLymphomaLymphoma T-Cell Cutaneousstomatognathic diseasesmedicine.anatomical_structurehepatosplenic T-cell lymphomaOncologyImmunologyBone marrowbusinessHuman
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